Recent advancements in text-to-image (T2I) and vision-language-to-image (VL2I) generation have made significant strides. However, the generation from generalized vision-language inputs, especially involving multiple images, remains under-explored. This paper presents Kosmos-G, a model that leverages the advanced perception capabilities of Multimodal Large Language Models (MLLMs) to tackle the aforementioned challenge. Our approach aligns the output space of MLLM with CLIP using the textual modality as an anchor and performs compositional instruction tuning on curated data. Kosmos-G demonstrates a unique capability of zero-shot multi-entity subject-driven generation. Notably, the score distillation instruction tuning requires no modifications to the image decoder. This allows for a seamless substitution of CLIP and effortless integration with a myriad of U-Net techniques ranging from fine-grained controls to personalized image decoder variants. We posit Kosmos-G as an initial attempt towards the goal of ``image as a foreign language in image generation.''